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Beginning of Paper
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Alzheimer's: Genetic Dementia
Alzheimer's, the disease of the degeneration of the brain, was
identified in 1907 by German physician Alois Alzheimer. Four million
Americans suffer from the disease which deprives the victim of the ability
to remember, think, reason, and eventually coordinate movement. This most
common form of dementia ....
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Middle of Paper
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.... alpha-2-macrogobulin, A2M, a gene
mutation on chromosome 12. A2M is a protein that deactivates proteases,
enzymes that carve up other proteins. Alpha-2-macrogobulin's involvement
in Alzheimer's development is especially likely because it attaches to the
same cell surface protein as APOE and amyloid precursor-protein (APP). The
unmutated form of A2M helps to get rid of the APP fragment beta-amyloid,
which is present in excess amounts in the brains of Alzheimer's patients.
The mutant A2M, which does not properly remove protein, but only makes the
aging brain vulnerable; it doe ....
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SUBJECTS
