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Beginning of Paper
Alzheimer's: Genetic Dementia

Alzheimer's, the disease of the degeneration of the brain, was identified in 1907 by German physician Alois Alzheimer. Four million Americans suffer from the disease which deprives the victim of the ability to remember, think, reason, and eventually coordinate movement. This most common form of dementia ....

Middle of Paper
.... alpha-2-macrogobulin, A2M, a gene mutation on chromosome 12. A2M is a protein that deactivates proteases, enzymes that carve up other proteins. Alpha-2-macrogobulin's involvement in Alzheimer's development is especially likely because it attaches to the same cell surface protein as APOE and amyloid precursor-protein (APP). The unmutated form of A2M helps to get rid of the APP fragment beta-amyloid, which is present in excess amounts in the brains of Alzheimer's patients. The mutant A2M, which does not properly remove protein, but only makes the aging brain vulnera ....

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