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Beginning of Paper
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Huntington's Disease
Huntington's disease is inherited as an autosomal dominant disease that gives
rise to progressive, elective (localized) neural cell death associated with
choleric movements (uncontrollable movements of the arms, legs, and face) and
dementia. It is one of the more common inherited brain disorders. Abou ....
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Middle of Paper
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.... tissues from three cortical regions were taken during an autopsy
(from the 22 HD symptomatic HD patients): frontal lobe, temporal lobe and
occipital lobe, and putamen. Molecular analyses were performed on genetic DNA
isolated from 200 mg of frozen brain regions as described above. The HD
diagnosis was confirmed in patients by PCR amplification of the trinucleotide
repeat in the IT 15 gene. One group was screened with primers that included
polymorphism and the other was screened without the polymorphism. After heating
the reaction to 94 degrees C for 4 m ....
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SUBJECTS
